What is Healicoll?

 

Healicoll is an acellular dermal matrix derived from bovine Type-1 collagen. Healicoll is ultra-pure through the patented manufacturing process making it safe for patients of all ages.

 

Indications

 

Healicoll has been proven to effectively treat the following types of wounds:

• - Venous ulcers
• - Diabetic ulcers
• - Pressure ulcers
• - Chronic vascular ulcers
• - Skin Donor Sites for Grafts
• - 2nd Degree Burns
• - Trauma wounds: abrasions, lacerations, and skin tears
• - Surgical wounds: post-Mohs’ surgery, post-laser surgery, podiatric, wound dehiscence
• - Partial and full-thickness wounds

 

How does Healicoll work?

 

Healicoll has been proven to granulate tissue in 4-5 days by creating rapid neo-vascularization. Full molecules of collagen provide up to 3,000 receptor sites for your body's own growth factors to attach to and begin tissue regeneration. Healicoll reduces inflammation which helps reduce pain, and kick starts the healing process. Healicoll has proven to successfully heal wounds of all types and burns, for patients of all ages including those with additional health issues affecting their healing.

 

How is it Applied?

 

Simple, fast application procedure:

• - Remove from package and separate clear backing from product.
• - Soak in sterile saline or water for 5 minutes.
• - Fenestrate if exudate is present.
• - Apply to wound bed, remove any air bubbles.
• - Refer to the Healicoll Layering Guide for dressing recommendations.

For surgical settings: Healicoll can be sutured or stapled in place as needed.

 

What is Healicoll Made of?

 

How Healicoll™ Collagen Differs From Other Collagen Dermal Replacements

Collagen exposed during wound formation activates the clotting phase and migrates the inflammatory cells to the wound bed. If the matrix made of collagen is native, pure and non-immunogenic, it will posses all the natural binding sites to all the cytokines, including epidermal growth factor (EGF), fibronectin, fibrinogen, histamine, platelet derived growth factor (PDGF), serotonin, and von Willebrand factor etc…A cross-linked or contaminated Type III collagen cannot effectively achieve such wound healing characteristics.

Additionally, a native collagen dressing also has cell membrane binding sites that would attract the neutrophil, for debris scavenging, bacteria destruction, and leukocytes along with the macrophages/monocytes, for wound healing via secretion of enzymes and cytokines for tissue reconstruction.

Subsequently, epithelialization, angiogenesis, granulation tissue formation, and collagen deposition are the principal steps in this anabolic portion of wound healing. It is also hypothesized that the native Type-I collagen creates adhesion sites for growth factors and it would trigger a phenomenon called "Cell Signal Transduction" through which the floating stem cells are converted to appropriate cell-lines to regenerate the damaged tissue.

The other collagen preparations, mostly contaminated with type-III collagen, elastin, lipids and other immunogenic proteins, following chemical cross-linking, that is required to minimize their immunogenicity, does not maintain the native chemistry of collagen and thereby loses its bioactivity and also other binding abilities and significantly impaired with its wound healing abilities.

The illustration below depicts the behavior of cross-linked collagen vs. non-crosslinked collagen.

 

Healicoll Saftey Information

 

Healicoll has been applied to patients tens of thousands of times with no adverse events or reactions. If you have a beef allergy you may want to discuss this with your physician prior to application of Healicoll as it is comprised of Bovine collagen.

 

After Care

 

Once Healicoll has been applied, do not disturb the wound or remove Healicoll. For scheduled dressing changes or weekly follow up, additional layers of Healicoll can be applied right over any remaining collagen in the wound bed..

 

IMPORTANT: Healicoll is always to remain directly onto the wound and never removed or wiped off during a dressing change.